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Our resources accessed from the list below give a flavor of the variety of liquid chromatography analyses that can be addressed using the Axcend Focus LC®.

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App Note

Capillary-Scale Radiopharmaceutical Analysis using the Axcend Focus LC®

The production and validation of radiopharmaceutical compounds result in generation of radioactive solvent waste. These waste streams must be stored for a sufficient time to allow for decay to occur...

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App Note

Capillary-Scale Analysis of Nontoxic Antibody Drug Conjugate (ADC) Mimics

Antibody drug conjugates (ADCs) belong to a class of drugs featuring a monoclonal antibody conjugated to a toxic payload. The antibody allows for the delivery of this payload to specific antigen...

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App Note

Capillary-Scale Size Exclusion Chromatography Using the Axcend Focus LC®

Size exclusion chromatography (SEC) is a technique often used to resolve large molecules based off their hydrodynamic radius (or size). This technique is widely used for the analysis of...

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App Note

Analysis of Benzodiazepines Using Portable LC-MS Instrumentation

Mass spectrometry (MS) is a powerful detection method that provides high sensitivity and structural information of an analyte. Liquid chromatography (LC) is commonly used as a separation technique...

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App Note

On-Line Monitoring of a Heterogenous Reaction Using the Axcend InFocus™ Automated Sampler and...

On-line sampling and analysis of heterogenous reaction mixtures is a critical application of modern process analytical technology (PAT). This application note describes the monitoring of a...

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App Note

Assessing Ibuprofen in Mini-Tablets Using the Axcend Focus LC® Micro-HPLC-UV System

This study compares two analytical methods—UV spectrophotometry and micro-HPLC-UV—for quantifying ibuprofen content in pediatric mini-tablets. While both methods demonstrated acceptable linearity,...

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App Note

Low Flow Direct Infusion Mass Spectrometry Using AutoFocus™

Direct infusion mass spectrometry is a common technique for screening for both qualitative and quantitative analysis. In many direct infusion setups, samples are manually loaded into a syringe before...

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App Note

MDA Quantification in Jet Fuel

ASTM D1655, Standard Specification for Aviation Turbine Fuels, defines a maximum allowable limit for Metal Deactivator Additive (MDA) in jet fuel. ASTM D8545 is currently the only ASTM-published...

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App Note

Adapting Pharmaceutical Monographs for Capillary Scale HPLC Using USP 621 Guidelines

Abstract Compact capillary scale liquid chromatography (LC) instrumentation offers a platform for high performance separations with considerable reduction in solvent consumption, operating cost, and...

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App Note

Small-Footprint Capillary UHPLC/MS Technology Significantly Reducing Consumption of PFAS Containing...

Poster Reprint ASMS 2025 Poster number MP 230 Introduction Synthetic oligonucleotides are important biotherapeutic drugs because of their broad applications in genetic research, drug development,...

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App Note

Validating Repeatability Performance of the Axcend Focus LC®: Single- and Multi-Day Study

Abstract Innovative tools that purport to improve workflows through saving time, space, or cost must also provide analytical results that are nominally the same or better than incumbent technologies....

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App Note

Determination of Pharmaceuticals by Capillary HPLC-MS/MS

Abstract This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for...

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October 25-28, 2026

Join us at AAPS PharmSci360! AAPS is the convener of the pharmaceutical science community, bringing...

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November 16-18, 2026

Find us at this year's Eastern Analytical Symposium (EAS)! EAS has been the leading conference in...

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