HPLC 2026

Come find us at the 55th International Symposium on High Performance Liquid Phase Separations and Related Techniques! This scientific symposium series proudly stands as the world's foremost conference on liquid phase separations and related innovations, featuring analytical instrumentation and chromatography innovations.

Event Details

DATES: June 6-11, 2026

LOCATION: Indianapolis, IN

BOOTH: 9

Our Presentations

Be sure to attend our presentations throughout the conference to hear the latest data and insights from our experts and collaborators.

Reducing Solvent Consumption in Radiopharmaceutical Analysis Using Capillary LC

POSTER | Tuesday, June 9 | 3:00 - 4:30 PM | Griffin Hall | Sam Foster, Axcend

Radiopharmaceuticals are a class of medication often used in the treatment of cancer. These drugs utilize a compound labeled with a radionuclide to deliver targeted radiation to cancer cells. Due to the inherent radioactive decay of these treatments, compounds must be labeled hours to days before administration. LC is used to determine radiopharmaceutical purity and strength. Waste solvents resulting from this preparation and analysis must be stored until 10 half-lives of radioactive decay have occurred. This leads to months or years of additional storage times, resulting in high disposal costs and environmental risks. Capillary-scale LC operates at flow rates orders of magnitude less than analytical scale (µL/min), reducing solvent consumption, operating costs, and environmental concerns. This poster will demonstrate the use of capillary-scale LC in radiopharmaceutical workflows of both small and large molecules. Multiple radionuclides will be analyzed to determine system repeatability, and sensitivity between isotopes of various energies. These works are a significant step forward in producing more sustainable alternatives to existing workflows. 

From Our Collaborators: Focus LC in Action

Explore how researchers and industry experts are using Axcend’s small-footprint LC systems in real-world applications. These partner-led presentations highlight innovative approaches made possible by our Focus LC. 

Development and Implementation of Capillary Scale PAT For On-Line Dilution and Reaction Monitoring

PRESENTATION | Monday, June 8 | 1:30 - 3:00 PM | White River G-J | Angel Diaz, Pfizer

Process analytical technologies (PAT) have been implemented into pharmaceutical manufacturing workflows to provide insights into reaction or process dynamics and monitor critical process parameters (CPPs). Liquid chromatography (LC) has been used in PAT to resolve complex mixtures allowing each analyte to be analyzed separately. Currently, analytical scale LC workflows can generate large volumes of hazardous mobile phase solvents, especially during long reactions, and require repetitive sampling volumes that gradually remove reactants and products, which changes the reaction conditions. By reducing the system to the capillary scale, small internal diameter columns, fittings, and transfer lines can be utilized, which significantly reduces solvent usage and reaction volume consumption. The reduction in scale allows for compact form factors, enabling co-location of the system and reaction vessel. This eliminates the need for long transfer tubing and reduces lag time between sample withdraw and analysis. In this work, we describe the development and implementation of capillary scale PAT systems for on-line sampling, dilution, and analysis of reaction mixtures. These results are compared to existing analytical results with respect to maintaining reaction integrity, chromatographic efficiency, sensitivity, repeatability, and analytical method greenness score (AMGS). This work demonstrates the potential for capillary scale instrumentation to provide greener and more cost-effective alternatives to traditional workflows.