Understanding Capillary LC - Part 2: Solvent Delivery Systems

Solvent delivery is a critical component of any liquid chromatography system, and at the capillary scale, the choice of pumping mechanism can make or break performance. In the second installment of our Understanding Capillary LC webinar series, Axcend Scientist Dr. Sam Foster will take a deep dive into the unique demands of solvent delivery in capillary-scale LC.

This session will compare and contrast the primary pumping technologies used today - including piston, syringe, pneumatic, and electroosmotic systems - and discuss the tradeoffs of each in terms of flow stability, pressure control, footprint, and compatibility with microflow applications. You'll gain insight into where each system excels and where it falls short, as well as a behind-the-scenes look at the technology Axcend employs in the Focus LC, including our method of solvent generation and flow control.

Whether you're new to capillary LC or refining your approach, this webinar will equip you with a clearer understanding of how solvent delivery impacts your results.

Key Takeaways:

• The pros and cons of common capillary LC pumping systems
• How flow rate, pressure, and system design influence performance
• Why Axcend's solvent delivery approach is uniquely suited for capillary applications

Webinar

Speaker

Samuel Foster, Ph.D.
Application Scientist
Axcend

Samuel Foster completed his Ph.D. in Pharmaceutical Chemistry from Rowan University in 2025. His research has focused on the development and application of capillary scale liquid chromatography instrumentation. He currently works at Axcend as an application scientist focusing on the development of chromatographic workflows for a variety of analyte classes including oligonucleotides, monoclonal antibodies, and drugs of abuse.