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Our resources accessed from the list below give a flavor of the variety of liquid chromatography analyses that can be addressed using the Axcend Focus LC®.

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App Note

Capillary-Scale Analysis of Nontoxic Antibody Drug Conjugate (ADC) Mimics

Antibody drug conjugates (ADCs) belong to a class of drugs featuring a monoclonal antibody conjugated to a toxic payload. The antibody allows for the delivery of this payload to specific antigen...

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App Note

Capillary-Scale Size Exclusion Chromatography Using the Axcend Focus LC®

Size exclusion chromatography (SEC) is a technique often used to resolve large molecules based off their hydrodynamic radius (or size). This technique is widely used for the analysis of...

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App Note

Analysis of Benzodiazepines Using Portable LC-MS Instrumentation

Mass spectrometry (MS) is a powerful detection method that provides high sensitivity and structural information of an analyte. Liquid chromatography (LC) is commonly used as a separation technique...

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App Note

On-Line Monitoring of a Heterogenous Reaction Using the Axcend InFocus™ Automated Sampler and...

On-line sampling and analysis of heterogenous reaction mixtures is a critical application of modern process analytical technology (PAT). This application note describes the monitoring of a...

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Webinar
Webinar snapshot showing a comparison of analytical scale and capillary scale liquid chromatography for a USP monograph of hydrochlorothiazide.

Adapting HPLC to the Capillary Scale: Insights from Academia and Industry

November 3, 2025

Learn how scientists are adapting analytical high-performance liquid chromatography (HPLC) methods to the capillary scale—cutting solvent use, improving sensitivity, and adapting validated...

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App Note

Assessing Ibuprofen in Mini-Tablets Using the Axcend Focus LC® Micro-HPLC-UV System

This study compares two analytical methods—UV spectrophotometry and micro-HPLC-UV—for quantifying ibuprofen content in pediatric mini-tablets. While both methods demonstrated acceptable linearity,...

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App Note

Low Flow Direct Infusion Mass Spectrometry Using AutoFocus™

Direct infusion mass spectrometry is a common technique for screening for both qualitative and quantitative analysis. In many direct infusion setups, samples are manually loaded into a syringe before...

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Immersion Probe Raman for Pharmaceutical Suspension Testing in the Manufacturing Plant and...

Abstract Traditional analysis of pharmaceutical suspensions by liquid chromatography requires time, manual sample preparation, and solvents. In this work, we explored an alternative procedure for...

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App Note

Adapting Pharmaceutical Monographs for Capillary Scale HPLC Using USP 621 Guidelines

Abstract Compact capillary scale liquid chromatography (LC) instrumentation offers a platform for high performance separations with considerable reduction in solvent consumption, operating cost, and...

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Poster

Micro-HPLC-UV Method for Assessing Ibuprofen Content in Pediatric Mini-Tablets and Identification...

Introduction Age-appropriate pharmaceutical formulations are crucial for ensuring safe and effective drug administration. Mini-tablets (2 mm, 10 mg, Figure 1a and 1b) offer a promising solution in...

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Webinar

Reducing PFAS in Oligonucleotide Analysis: A New Path Forward

June 24, 2025

Synthetic oligonucleotides are increasingly central to modern research and therapeutic development. But their analysis via LC/MS often relies on large volumes of hazardous mobile phase additives like...

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Poster

New Compact Sampling and Sample Preparation Technologies for Portable Capillary Liquid...

High performance liquid chromatography (HPLC) is one of the most used analytical techniques in the world. Traditional analytical scale instrumentation consumes ~50 L of solvent per year, with a...

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AAPS PharmSci360

October 25-28, 2026

Join us at AAPS PharmSci360! AAPS is the convener of the pharmaceutical science community, bringing...

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Eastern Analytical Symposium

November 16-18, 2026

Find us at this year's Eastern Analytical Symposium (EAS)! EAS has been the leading conference in...

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