IFPAC

Come find us at IFPAC this year! Process Analytical Technology is one of the most exciting and important advanced technology areas meeting both the current challenges, as well as the future needs of industry. Each year the IFPAC Scientific Board consisting of industry, regulatory, and academic leaders works collaboratively to create a comprehensive program that addresses important mainstay topics, as well as the latest trends, technologies and applications. 

Event Details

DATES: March 2-4, 2026

LOCATION: Bethesda, MD

BOOTH: 503

Our Presentations

Be sure to attend our presentations throughout the conference to hear the latest data and insights from our experts and collaborators.

On-line PAT Monitoring of Heterogeneous Suzuki Coupling via Regenerative Capillary LC Sampling

PRESENTATION | Wednesday, March 4 | 7:50 AM - 12:00 PM | Grand Ballroom G | Matthew Morse, Axcend

The Suzuki coupling is a widely used reaction in pharmaceutical manufacturing for C-C bond formation, often relying on solid-phase palladium catalysts for easy recovery. However, these solid catalysts typically cause clogging in automated monitoring workflows. The objective of this work was to develop a robust, continuous process analytical technology (PAT) solution for monitoring reaction slurries while minimizing clogging risks. Using the Axcend InFocus PAT system and a novel multiconfiguration valve with custom channel technology, microliter aliquots of the reaction slurry can be withdrawn, filtered, and analyzed using sub-microliter sample injection and capillary-scale liquid chromatography (LC). The integrated system effectively regenerates the filter by reversing flow to waste, reducing clogging risks, and reclaiming the catalyst. This approach enables continuous, reliable monitoring of heterogeneous reactions, marking a significant advance in small-volume PAT workflows for enhanced process efficiency and control in pharmaceutical bioprocessing.

From Our Collaborators: Focus LC in Action

Explore how researchers and industry experts are using Axcend’s small-footprint LC systems in real-world applications. These partner-led presentations highlight innovative approaches made possible by our Focus LC. 

Development of a Direct Sampling Module for Compact Capillary Liquid Chromatography

PRESENTATION | Monday, March 2 | 1:05 - 5:40 PM | Forest Glen Conference Room | Jim Grinias, Rowan University

The automation of reaction monitoring analysis can greatly improve the capability to obtain real-time feedback on reaction progress and aid in method optimization. Liquid chromatography (LC) is a widely used analytical technique for organic reaction monitoring, but the large size of the instrumentation can make online analysis difficult and impractical. Compact and miniaturized LC instrumentation provides the opportunity to simplify the process of analyzing samples at the reaction site, but the smaller scale of capillary LC columns is often incompatible with commercial reaction sampling systems designed to work with larger volumes. Here, a compact sampling module (CSM) designed to automate sample collection from a variety of reaction devices with volumes that are compatible with capillary LC is reported. The design and operation of the system are described, as well as example uses within a conventional medicinal chemistry setting. Specifically, the real-time analysis of both standard reactions in flow and batch settings with sampling performed by the CSM is described. Furthermore, the utility of the module in analyzing photoredox-based reactions, which are currently experiencing significant growth within drug discovery, is detailed. Performance of the system is compared to a traditional benchtop LC instrument that is currently used as the primary platform for standard reaction analysis is also discussed.